NFL picks against the spread: Betting picks for Sunday afternoon games Week 10


Nov. 15, 2026, 12:16 p.m. MT

The Sunday schedule in Week 10 kicked off with an international game in the morning and then had seven games in the early 1 p.m. ET time slot.

The late afternoon slate has only three games, all involving the NFC West.

That gives you three opportunities to make a little money on the outcome of those games, betting the moneyline (winner), spread or total (over/under).

If you are on to participate in such activities and you haven’t placed your wagers yet, here are my picks for those three games and their outcomes.

Odds come from BetMGM Sportsbook.

  • Moneyline: Rams -500
  • Spread: Rams -10 (-105)
  • Total: Under 38.5 (-110)
  • Moneyline: Seahawks -295
  • Spread: Seahawks -6.5 (-108)
  • Total: Over 40.5 (-108)

49ers at Cowboys

  • Moneyline: 49ers -210
  • Spread: 49ers -4 (-108)
  • Total: Under 56 (-110)

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